THE STABILITY OF HEROIN METABOLITES AND ADULTERANTS IN BLOOD TO EVALUATE ROLE OF THE STABILITY ON POSTMORTEM REDISTRIBUTION

The present study aimed to investigate the stability of morphine, morphine-3-β-glucuronide (M3G), morphine-6-β-glucuronide (M6G), 6-acetylmorphine (6-AM) from heroin metabolites, and codeine, codeine-6-glucuronide, nor-codeine, fentanyl, norfentanyl, paracetamol, caffeine its adulterants at room temperature for 24 hours in order understand effect instability postmortem redistribution (PMR). metabolites were spiked into control blood sample with standard addition method. Then they kept 4 samples prepared by liquid-liquid extraction analyzed using validated analytical method a liquid-chromatography-tandem mass spectrometry. According results this study, no significant changes observed analyte concentrations 4- 24-hour blood, it is thought that other mechanisms may be more responsible than analytes concentration PMR.